High‑Purity Human Menopausal Gonadotropin for Research

HMG 75 IU (Human Menopausal Gonadotropin) is a purified preparation containing a standardized 1:1 ratio of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). It is one of the most extensively studied gonadotropin preparations in reproductive endocrinology. At china grey peptides company, we supply wholesale HMG 75 IU with verified >99% purity to research facilities across the USA, Canada, the United Kingdom, and Europe. This guide covers its mechanism, research applications, purity requirements, and safe handling – so you can make an informed wholesale purchase.

What Is HMG 75 IU? (Mechanism of Action)

Human Menopausal Gonadotropin (HMG) is a gonadotropin preparation extracted from the urine of postmenopausal women, where FSH and LH production is naturally elevated. Modern HMG preparations contain 75 IU of FSH and 75 IU of LH per vial – a balanced 1:1 ratio that provides comprehensive stimulation of gonadal tissues. The first clinically usable form of HMG was isolated by Piero Donini in 1949 and introduced into use by Bruno Lunenfeld in 1961. Today, highly purified HMG (HP-hMG) is suitable for precise laboratory handling.

The mechanism of action follows the two-cell, two‑gonadotropin model of follicular steroidogenesis:

• FSH targets granulosa cells in the ovaries, promoting follicular development and estrogen production

• LH acts on theca cells, stimulating androgen production (androstenedione and testosterone)

• Together, they drive follicular growth, steroidogenesis, and – when combined with appropriate triggers – ovulation.

Upon administration, HMG binds to FSH and LH receptors on target cells, activating cyclic adenosine monophosphate (cAMP) signaling pathways. This triggers a cascade leading to follicular growth, maturation, and eventual ovulation in appropriate models. The balanced FSH and LH content provides comprehensive gonadotropic stimulation, often resulting in more physiological hormone profiles compared to single-hormone preparations.

Pharmacokinetically, HMG demonstrates excellent bioavailability when administered subcutaneously or intramuscularly. Peak serum concentrations are typically achieved within 12-24 hours, with a half‑life ranging from 24-36 hours – allowing for convenient dosing schedules.

Key Research Effects of HMG 75 IU

• Follicular Development Studies – Investigates the role of balanced FSH/LH stimulation in ovarian folliculogenesis

• Spermatogenesis Research – Studies testicular steroidogenesis and sperm production cycles

• Ovarian Stimulation Protocols – Evaluates different gonadotropin combinations in ART models

• Endometrial Receptivity – Explores the relationship between gonadotropin ratios and endometrial thickness

• PCOS Models – Examines predictable responses to precise hormonal regulation

• Two‑Cell Theory Validation – Tests the classical model of follicular steroidogenesis

⚠️ Research use only – HMG is not approved for human therapeutic use as a research chemical. It is strictly for in vitro and laboratory animal studies. WADA classifies HMG as a prohibited substance under Section S2 (Peptide Hormones, Growth Factors, and Related Substances). Gonadotrophins (LH, hCG) are listed as prohibited in both men and women.

Why Choose china grey peptides company for HMG 75 IU?

We understand that peptide purity directly affects receptor binding assays, cell signaling studies, and in vivo models. Here is what we guarantee:

Our Quality Promise

• No Impurities – Single peak by HPLC; each batch is assayed for IU potency of both FSH and LH fractions

• Batch Traceability – Each COA includes retention time, purity %, and residual solvent analysis

• Low Endotoxin – <1 EU/mg for cell culture applications

• Manufactured under cGMP conditions to ensure high bioactivity and purity

• Vacuum‑Sealed Vials – Prevent moisture absorption and maintain stability

• Fast Turnaround – Orders ship within 24 hours on business days

Recent Research on HMG 75 IU (2024–2025)

Staying current with peer‑reviewed literature is part of our E‑E‑A‑T commitment. Here are key recent findings:

🧬 LH Supplementation in IVF (2024)

A 2024 study published in the Journal of Obstetrics and Gynaecology Research compared LH supplementation with hMG versus low‑dose hCG during ovarian stimulation. The study analyzed 468 unique stimulation cycles (hMG: 75–250 IU; low‑dose hCG: 50–100 IU). Results showed that fresh and frozen IVF‑ET pregnancy outcomes were comparable after hMG versus low‑dose hCG supplementation, suggesting flexibility in supplemental LH dosing regimens that may address research preference or cost concerns.

🧬 HMG + r-LH Improves Pregnancy Outcomes (2024)

A 2024 study in the International Journal of Women‘s Health enrolled 456 infertile women undergoing IVF/ICSI. The study found that the addition of both HMG and recombinant LH (r-LH) to FSH improved pregnancy and birth outcomes, particularly in women over 32 years of age or with overweight/obesity – groups that typically face challenges in conceiving and sustaining a pregnancy. Endometrial thickness was greater in the HMG‑supplemented groups, suggesting better endometrial receptivity.

🧬 HMG Dosage and Ovarian Response (PMC)

Data from a published study (PMC7137506) showed that HMG dosage (75 IU/vial) was associated with improved endometrial thickness and estradiol levels when vitamin E was supplemented from the follicular phase. The research tracked ovulation rates (71.4‑77.3%) and clinical pregnancy rates (23.6‑28.2%) across different supplementation protocols.

🧬 30‑Year Review of HCG/LH Supplementation (2025)

A comprehensive 30‑year review published in Reproductive BioMedicine Online (June 2025) evaluated the effect of HCG and LH supplementation during ovarian stimulation. The review found that while r‑FSH appeared more potent than urinary FSH, HMG recruited fewer follicles but resulted in slightly higher pregnancy rates after a first fresh embryo transfer. The conclusion noted that the beneficial effect of HCG and LH supplementation on clinical outcome has never been definitely proven for any of the combined gonadotropin products, highlighting the need for continued research.

🧬 Low‑Dose HMG Superior to Clomiphene

A randomized controlled trial demonstrated that ovarian stimulation with low‑dose hMG (starting at 75 IU/day) is superior to clomiphene citrate in intrauterine insemination cycles with respect to clinical pregnancy rate. This suggests better reproductive outcomes after ovarian stimulation with low‑dose gonadotropins.

How to Buy HMG 75 IU for Research (Wholesale)

If your lab needs a reliable supply of HMG 75 IU, follow these steps:

1. Verify Your Research Status

We sell only to qualified research institutions, laboratories, and registered businesses. Provide a valid tax ID or institutional email.

2. Request the Current COA

Before ordering, ask for the Certificate of Analysis for the batch you will receive. Look for:

• Purity ≥99% by HPLC

• IU potency of both FSH and LH fractions

• Low endotoxin levels (<1 EU/mg)

3. Choose Your Quantity

We offer wholesale from 10 vials up to 1,000+ vials. Contact us for bulk pricing.

4. Place Your Order

Use the form below or email sales@chinagreypeptidescompany.com. We ship within 24 hours on business days.

Frequently Asked Questions (FAQ)

❓ What is HMG 75 IU?

HMG 75 IU (Human Menopausal Gonadotropin) is a purified gonadotropin preparation containing 75 IU of follicle-stimulating hormone (FSH) and 75 IU of luteinizing hormone (LH) in a 1:1 ratio – the classic standard preparation. It is extensively studied in reproductive endocrinology for its role in gametogenesis and steroidogenesis.

❓ How does HMG 75 IU work?

HMG binds to FSH and LH receptors on ovarian and testicular cells, activating cAMP signaling pathways. FSH promotes follicular development, while LH stimulates androgen production – together driving gametogenesis and steroidogenesis in a coordinated manner.

❓ What is the typical dosage of HMG in research studies?

Research protocols vary widely. Standard initial dosing in animal models typically ranges from 75-150 IU daily, administered subcutaneously or intramuscularly. In published studies, HMG dosages of 75‑250 IU have been used during stimulation cycles. Always design your own protocol based on published literature.

❓ How do I reconstitute HMG 75 IU?

Add sterile bacteriostatic water or 0.9% saline to the vial. Gently swirl – do not shake. Store reconstituted HMG at 2‑8°C for up to 4 weeks, or freeze in aliquots at –20°C for up to 6 months. The lyophilized powder is stable for up to 24 months when stored at –20°C.

❓ Is HMG 75 IU legal to buy in the USA?

Yes, for research purposes only. It is not a controlled substance but is prohibited in athletic competition by WADA under Section S2 (Peptide Hormones). You must not use it in humans.

❓ Do you ship to Canada, UK, or Europe?

Yes. We ship to all research addresses in Canada, United Kingdom, and Europe with proper customs documentation. Import permits may be required – please check local regulations.

❓ What is the CAS number for HMG 75 IU?

The CAS number for HMG 75 IU is 90779-69-4.

❓ What is the difference between HMG and recombinant FSH (r‑FSH)?

HMG contains both FSH and LH in a 1:1 ratio, mimicking the body’s natural gonadotropin balance. r‑FSH contains only FSH. Research shows that HMG recruits fewer follicles but may result in slightly higher pregnancy rates after fresh embryo transfer, possibly due to the LH component.

1. Link from the FAQ to your “Certificate of Analysis – https://chinagreypeptidescompany.com/about-us/

2. Link from the “How to Buy” section to your “Wholesale Inquiry Form” page

• PubMed – 30‑Year Review of HCG/LH Supplementation (2025)
  https://pubmed.ncbi.nlm.nih.gov/40294495/

• WADA 2026 Prohibited List – S2 Peptide Hormones
  https://www.wada-ama.org/en/prohibited-list

• PMC – HMG Dosage and Ovarian Response Data
  https://pmc.ncbi.nlm.nih.gov/articles/PMC7137506/

 Secure High‑Purity HMG 75 IU for Your Lab

HMG 75 IU remains a cornerstone in reproductive endocrinology research, offering a balanced 1:1 FSH/LH ratio that has been studied for over six decades. To achieve reproducible, publication‑ready data, you need >99% purity, batch‑specific COAs, and a supplier who prioritizes quality and compliance.

china grey peptides company delivers exactly that – wholesale HMG 75 IU to the USA, Canada, UK, and Europe, backed by third‑party testing and fast shipping.

👉 Ready to place a wholesale order?
[Click here to contact page  email us directly at sales@chinagreypeptidescompany.com